個人簡介

食品科技學院教授、博士生導師，武漢市“黃鶴英才”。農業農村部蜂産品質量安全控制重點實驗室學術委員會委員，中國養蜂學會副理事長、湖北省養蜂學會常務副理事長、武漢市現代都市農業産業技術體系——崗位專家、武漢市蜂産品質量工程控制技術研究中心主任、湖北省校企共建枸杞研發中心主任。湖北省科技廳專家庫高端專家，國家自然科學基金評審專家。主要在“食品功能因子與營養健康”、“蜂産品科學”和“特色農副産品精深加工與綜合利用”領域開展研究，包括：1.基于代謝組學技術與合成生物學思路研究益生菌對蜂産品的轉化與增效機制。2.聚焦我國特色蜂蜜中特征标志物挖掘并評估其健康效應。3.多種組學技術聯用解析膳食多酚與腸道微生物的互作機制，開展膳食多酚對糖脂代謝、動脈粥樣硬化、腸道健康、酒精性肝損傷、尿路感染調控效果與機制研究。4.探讨膳食多酚在食品熱加工過程中的代謝網絡與健康效應。5.特色農産品精深加工産品開發。

教育經曆

1989.9-1993.6：77779193永利官网食品科技系/食品科學專業，獲工學學士學位
1998.9-2004.6：77779193永利官网食品科技系/農産品加工及貯藏工程專業，碩博連讀獲工學博士學位

工作經曆

1993.7-1998.8：77779193永利官网食品科技系從事學生管理工作
1998.9-2004.6：77779193永利官网食品科技系攻讀博士學位
2002.6-至今：77779193永利官网食品科技學院（系）從事教學與科研

研究領域

1. 食品功能因子與分子營養
2. 蜂産品科學（特征性成分挖掘、産品加工、營養與安全的相關理論和應用技術研究）
3. 特色農副産品精深加工與副産物高值化利用

科研項目

主持包括國家自然科學基金面上項目3項、科技部“十四五”重點研發計劃-子項目、國家質檢總局公益性行業科研專項-子課題、湖北省重點研發計劃和課題4項、湖北省揭榜挂帥項目-課題、市場監管創新發展聯合基金重點項目-課題、湖北洪山實驗室重大專項-子項目，湖北省成果轉化項目，武漢市應用基礎前沿項目、恩施州創新團隊等，及企業合作項目。近年來主持的國家及部分省市項目如下：
人才項目：
1. 武漢市委組織部第五批“黃鶴英才計劃”.2017-2020.
食品功能因子與營養健康領域：
1. 國家自然科學基金面上項目.黃烷-3-醇低聚體的腸道菌群代謝組學及其特定代謝産物調節肝髒脂質代謝異常的作用機理研究. 2023-2026.
2. 國家自然科學基金面上項目.原花青素對膳食中丙烯酰胺及其誘導細胞毒性的抑制效果與作用機制.2017-2020.
3. 國家自然科學基金面上項目.高粱原花青素營養補充劑對口腔緻齲齒菌粘附的幹預及分子機制.2013-2016.
4. 湖北洪山實驗室重大項目——子項目.黑米健康價值的發掘和利用.2022-2024.
5. 中國農科院深圳基因組所合作資金資助項目.新型黑米的營養與食味品質研究及改善糖脂代謝的健康效應.2023-2025.
蜂産品科學領域：
1. 市場監管創新發展聯合基金重點項目-課題.2025-2028.
2. 湖北省重點研發計劃項目-課題,五倍子蜂蜜質量标準體系的構建.2024-2026.
3. 武漢市科技特派員“産學研”專項.蜂産品精深加工産品研發與高值化利用. 2024-2026.
4. 國家十四五重點研發計劃——子課題.中蜂産品高值利用關鍵技術研發與新産品創制. 2022-2025.
5. 湖北省重點研發計劃.蜂花粉的生物破壁技術及其産品研發.2022-2024.
6. 湖北省農業科技成果轉化資金.複方水飛薊蜂蜜花粉系列産品的中試與示範. 2020-2021.
7. 武漢市應用基礎前沿項目.蜂花粉生物工程轉化及其保護腸道健康的高值化利用研究. 2020-2022.
8. 武漢市農委項目.武漢市現代都市農業産業技術體系——蜂産業崗位， 2018.
9. 武漢市科技平台項目.武漢市蜂産品質量控制工程技術研究中心.2009-至今.
10. 武漢市應用基礎研究計劃項目.一種新型蜂産品的功能營養成分分析與活性評價. 2015-2016.
特色農副産品精深加工與副産物高值化利用領域：
1. 菜薹精深加工産品開發與高質化利用.湖北省揭榜挂帥項目-課題2，2024-2026
2. 湖北省重點研發計劃（鄉村振興科技支撐項目）—子項目.薹用蔬菜品質評價及高值化利用技術研發. 2022-2023.
3. 湖北省重點研發計劃（企業創新發展項目）—子項目.神農架特色漿果精深加工技術創新與産品研發. 2021-2023.
4. 恩施州重點創新團隊.枸杞母本園及加工産品質量控制體系的建設.2015-2017.
5. 國家質檢總局公益性行業科研專項——子項目，純果汁檢驗鑒定技術研究. 2012-2014.

成果獎勵

獲獎情況：
1. 作為主要完成人鑒定成果6項；制定地方标準3項。
2. 曾榮獲教育部科技進步一等獎和湖北省科技進步二等獎各1項；以及“中國糧油學會第二屆全國糧油優秀科技工作者”；“武漢市優秀科技特派員” ；“學校社會服務工作先進個人”等榮譽稱号。
3. 先後20次被評為“省優碩士學位論文”、“省優學士學位論文”、“校優秀博士學位論文”、“校優秀碩士學位論文”、校“創新論文”和大學生學科競賽等省級獎勵和國家級獎勵指導教師。
4. 獲得包括教學質量一等獎在内的教學質量獎、成果獎和管理獎7次。
5. 曾榮獲研究生指導教師‘教書育人獎’榮譽稱号。
發表文章：
在FOOD CHEM、FOOD FUNCT、FOOD RES INT、FOOD SCI HUM WELL、INT J BIOL MACROMOL、食品科學、中國食品學報、質譜學報、農業工程學報等期刊上發表研究論文100多篇。近年來（作為通訊作者被SCI和EI收錄）部分文章如下：
1. Min Liu, Jinxin Shen, Xiaoling Zhu, Tingting Ju, Benjamin P. Willing, Xin Wu, Qun Lu, Rui Liu*. Peanut Skin Procyanidins Regulate Insulin Signaling and Hepatic Metabolism in Diabetic Mice. Food Science and Human Wellness.2024.10accepted.
2. Yi Zhou, Xin Wu, Jinxin Shen, Daijun Yang, Qu Lu, Changjiang Long*, Rui Liu*. Widely targeted metabolomics analysis of nutrient changes in a new black rice variety 'Huamoxiang No.3' (Oryza sativa L. var. Glutinosa Matsum) under different cooking modes. Cereal Chemistry, 2024.101:1106-1117.
3. Fangfang Yan, Si Qin, Chengming Wang, Wolfram Weckwerth, Qun Lu*, Rui Liu*. Procyanidin A1 and its digestive products inhibit acrylamide-induced IPEC-J2 cell damage: apoptosis and cell cycle arrest. Food Science and Human Wellness. 2024-4-10 accepted。
4. Xin Wu, Xingxing Zhang, Min Liu, Yi Zhou, Qun Lu, Tang Tang，Rui Liu*. Widely targeted metabolomics provides insights into the effect of parboiling treatment on metabolite profiles of black rice and cooked black rice. Journal of Cereal Science. 2023,114,103810.
5. Li Zhao, Xingxing Zhang, Langzhi He, Yubing Li, Yue Yu, Qun Lu, Rui Liu*. Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: Protective effect of peanut skin procyanidins. Food Science and Human Wellness. 2024(13):3570-3581.封面文章.
6. Li Wang† , Ruonan Liu† , Fangfang Yan , Wanbing Chen , Mo Zhang , Qun Lu , Bijun Huang and Rui Liu*. A newly isolated intestinal bacterium involved in C-ring cleavage of flavan-3-ol monomers and antioxidant activity of the metabolites. Food & Function. 2024,15, 580-590.
7. Min Liu, Jinxin Shen, Xiaoling Zhu, Tingting Ju, Benjamin P. Willing, Xin Wu, Qun Lu, Rui Liu*. Peanut skin procyanidins reduce intestinal glucose transport protein expression, regulate serum metabolites and ameliorate hyperglycemia in diabetic mice. Food Research International. 2023,113471.
8. Xin Wu, Yi Zhou, Qun Lu, Rui Liu*. Ultrasonic-assisted immersion of parboiled treatment improves head rice yield and nutrition of black rice and provides a softer texture of cooked black rice. Ultrasonics Sonochemistry. 2023,95,106378.
9. Mingjuan Xu, Cheng Lv, Qun Lu, Rui Liu*.Oligomeric procyanidins combined with Parabacteroides distasonis ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and bile acid metabolism in ApoE-/- mice. Food Science and Human Wellness.2023.3.13accepted.
10. Fangfang Yan, Li Wang, Li Zhao, Chengming Wang, Qun Lu, Rui Liu *. Acrylamide in food: Occurrence, metabolism, molecular toxicity mechanism and detoxification by phytochemicals. Food and chemical toxicology. 2023,113696.
11. Fangfang Yan, Qun Lu, Chengming Wang*, Rui Liu*. Procyanidin A1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through MAPKs and Nrf2 pathways. Food Science and Human Wellness. 2024,13:1475-1484.
12. Wanbing Chen#, Ruonan Liu#, Xiaoling Zhu, Li Zhang, Qun Lu, Hong Yang, Rui Liu*. Microbial phenolic metabolites 3-(3′,4′-dihydroxyphenyl)propionic acid and 3′,4′-dihydroxyphenylacetic acid prevent obesity in mice fed high-fat diet. Food Science and Human Wellness. 2024, 13(1): 327-338.
13. Min Liu, Li Wang, Bijun Huang, Qun Lu, Rui Liu*. 3,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice. Life Sciences. 2022,305,120742.
14. Li Zhao, Fangfang Yan, Qun Lu, Cuie Tang, Xiaohong Wang*,Rui Liu*. Q-TOF LC/MS and NMR identification of structurally different A-type procyanidins from peanut skin and their inhibitory activities on acrylamide. Journal of the Science of Food and Agriculture. 2022.102:7062-7071.
15. Min Liu, Bijun Huang, Li Wang, Qun Lu, Rui Liu*.Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice. Journal of the Science of Food and Agriculture. 2022, 102(13):5935-5947.
16. Li Zhao, Xiue Jin, Yubing Li, YueYu, Langzhi He, Rui Liu*. Effects of A-type oligomer procyanidins on protein glycation using two glycation models coupled with spectroscopy, chromatography, and molecular docking. Food Research International. 2022,155,111068.
17. Bijun Huang, Li Wang, Min Liu, Xin Wu,Qun Lu, Rui Liu*. The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism. J Food Biochemistry.2022,46(7) :e14103.
18. Mingjuan Xu, Cheng Lv, Huixia Wang, Qun Lu, Mingxia Ye, Xiaoling Zhu*, Rui Liu*. Peanut skin extract ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and gut microbiota in ApoE-/- mice. Food Research International. 2022,154:111014.
19. Yan Fangfang; Chen Wanbing; Zhao Li; Lu Qun; Wang Chengming*; Liu Rui*. Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway. Food & Function, 2021, 12,11956-11965.
20. Wanbing Chen, Li Zhang, Li Zhao, Fangfang Yan, Xiaoling Zhu, Qun Lu, Rui Liu*. Metabolomic Profiles of A-Type Procyanidin Dimer and Trimer with Gut Microbiota in Vitro. Journal of Functional Foods. 2021.85,104637.
21. Li Zhao, Xiaoling Zhu, YueYu, Langzhi He, Yubing Li, Li Zhang*, Rui Liu*. Comprehensive analysis of the anti-glycation effect of peanut skin extract. Food Chemistry. 2021,362,130169.
22. Fangfang Yan, Liang Chen, Wanbing Chen, Li Zhao, Qun Lu*, Rui Liu*. Protective effect of procyanidin A-type dimers against H2O2-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway. Life Sciences. 2021,266,118908.
23. Fangfang Yan; Li Zhao; Wanbing Chen; Qun Lu; Chengming Wang*；Rui Liu*. Comparison of the inhibitory effects of procyanidins with different structures and their digestion products against acrylamide-induced cytotoxicity in IPEC-J2 cells. Journal of Functional Foods. 2020, 104073.
24. Wanbing Chen; Xiaoling Zhu; Qun Lu; et al; Rui Liu*. C-ring cleavage metabolites of catechin and epicatechin enhanced antioxidant activities through intestinal microbiota. Food Research International. 2020, 135,109271.
25. Li Zhao, Luming Wen, Qun Lu, Rui Liu*. Interaction mechanism between α-glucosidase and A-type trimer procyanidin revealed by integrated spectroscopic analysis techniques. International Journal of Biological Macromolecules. 2020，143，173-180.
26. Li Zhao#, Ting Zhou#, Fangfang Yan, et al, Rui Liu*. Synergistic inhibitory effects of procyanidin B2 and catechin on acrylamide in food matrix. Food Chemistry. 2019, 296:94-99.
27. Li Zhao#, Fang Wang#, Qun Lu*, Rui Liu*, et al. Study on interaction between sorghum procyanidins tetramer and human salivary α-amylase: Binding characteristic and structural analysis. International Journal of Biological Macromolecules. 2018.118:1136-1141.
28. JiannanYu#, Fangfang Yan#, Qun Lu*, Rui Lui*. Interaction between sorghum procyanidin tetramers and the catalytic region of glucosyltransferases-I from streptococcus mutants UA159. Food Research International. 2018,112:152-159.
29. Xin Cai#, Jianan Yu#, Liman Xu, Rui Liu* et al. The mechanism study in the interactions of sorghum procyanidins trimer with porcine pancreatic α-amylase. Food Chemistry. 2015,174（1）：291-298.
30. 劉若男，陳婉冰，等，劉睿*.基于代謝組學探究原花青素B1的腸道微生物代謝.中國食品學報(EI). 2022,9:13-23.
31. 劉若男，陳婉冰，等，劉睿*.黃烷-3-醇類化合物靶向代謝組定量方法研究.質譜學報（EI）. 2022,43(1):67-77.
32. 毋鑫，黃碧君，晏芳芳，等，劉睿*.黑米儲藏與加工方式對其加工品質及膳食多酚影響的研究進展.食品科學(EI)，2022,43（3）：362-370.
33. 劉若男，陳婉冰，晏芳芳，等，劉睿*.黃烷-3-醇類化合物吸收、代謝的特征與機制研究進展.食品科學(EI). 2021,42(21):213-222.
34. 黃甯馨，魯群，丁士勇*，劉睿*，等.主成分分析法優選枸杞乳酸菌發酵飲品發酵劑.農業工程學報(EI)，2021,37（7）:286-292.
35. 趙莉，盧凱，王小紅，劉睿*.花生紅衣中原花青素A1的分離鑒定及其對丙烯酰胺的抑制效果.食品科學(EI).2018，39（20）:1-6.
36. Huifang Zhang; Min Liu; Fanfen Song; Xiaoling Zhu; Qun Lu*; Rui Liu*. Fermentation enhances the amelioration effect of bee pollen on Caco-2 monolayer epithelial barrier dysfunction based on NF-κB-mediated MLCK-MLC signaling pathway. Food Research International. 2024(178):113938.37. ChengLv, MingjuanXu, Xinbiao Yang, Yanlun Feng, Yun Zhu, QunLu, Chengming Wang*, Rui Liu*.Identification of Phenolamines in Rape Bee Pollen and Its Protective Effect and Mechanism on Alcoholic Liver Injury. Food Science and Human Wellness. 2025,14(2): 9250031.（封面文章）.
38. Huifang Zhang; Xiaoling Zhu; Qian Huang; Li Zhang; Xiaohua Liu*; Qun Lu*; Rui Liu*. Antioxidant and anti-inflammatory activities of rape bee pollen after fermentation and their correlation with chemical components by ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry-based untargeted metabolomics. Food Chemistry. 2023,409,135342.
39. Huifang Zhang; Qun Lu*; Rui Liu*. Widely targeted metabolomics analysis reveals the effect of fermentation on the chemical composition of bee pollen. Food Chemistry, 2022，375, 131908.
40. Yue Ding#, Mingjuan Xu#, Qun Lu, et al, Rui Liu*. Combination of Honey with Metformin Enhances Glucose Metabolism and Meliorates Hepatic and Nephritic Dysfunction in STZ-Induced Diabetic Mice. Food & Function.2019,10,7576-7587.
41. Shiqin Peng#, Ping Wei#, Qun Lu*, Rui Liu* et al. Beneficial effects of poplar buds on hyperglycemia, dyslipidemia, oxidative stress and inflammation in streptozotocin-induced type 2 diabetes. Journal of Immunology Research. 2018，Article ID 7245956.

其它

作為第一發明人的發明專利（申請發明專利20項，授權13項）：
1. 高粱原花青素混合物的制備方法及其抗齲齒應用（授權）.
2. 一種從高粱外種皮中提取原花青素四聚體的制備方法及應用（授權）.
3. 一種檢測葡萄汁中多種有機酸的含量及其真僞的方法（授權）.
4. 一種佛掌山藥速溶飲料的制備方法（授權）.
5. 一種低熱量藠頭面包及其制備方法（授權）.
6. 一種巢蜜舒咽噴霧劑及其制備方法（授權）
7. 一種高膳食纖維全藕粉的制備方法（申請）.
8. 一種雄蜂蛹小分子抗氧化肽的制備方法及其雄蜂蛹小分子抗氧化肽的應用（申請）.
9. 一種複方花粉膏幹粉及其制備方法和應用（申請）.
10. 一種複方花粉膏丸及其制備方法（授權）.
11. 一種含枸杞酒渣的酥性餅幹及其制備方法（申請）.
12. 楊樹芽提取物在制備脂肪氧合酶抑制劑中的用途（授權）.
13.一株從蜂糧中分離的枯草芽孢杆菌及其應用（授權）.
14. 一株巴士鍊球菌及其在生物合成兒茶素衍生物中的應用（授權）.
15.楊樹芽提取物作為飼料添加劑的用途及相應飼料（申請）.
16. 一種微生物發酵制備蜂蛹抗氧化肽的方法（申請）.
17. 一種油菜薹幹制加工的工藝方法（申請）.
18. 一種蒸谷黑米加工方法（申請）.
其它：
1. 主持和作為核心成員參加包括“國家特色專業”、“省級一流本科課程”、“省級精品課程”、“省級教學團隊”、“百門精品實踐課程”和“研究生精品示範課”、“研究生聯合培養實踐基地”等教改和教研項目20項。參加國家精品課程配套教材《食品分析》的編寫，科學出版社。
2. 指導研究生獲批“學校優碩培植計劃”；指導博士、碩士研究生6人次獲批省優和校優學位論文。
3. 指導3名博士生受CSC資助在比利時根特大學、加拿大阿爾伯塔大學和奧地利維也納大學聯合培養。
目前在讀碩士和博士研究生20多人，歡迎具有蜂産品科學、分子營養、代謝組學、合成生物學、高分辨質譜和NMR分析等背景和興趣的莘莘學子加入實驗室!