2024年12月11日，77779193永利官网李斌教授團隊梁宏閃副教授課題組在國際食品Top期刊《Journal of Agricultural and Food Chemistry》（Q1，IF=5.7）發表題為“Citrus Polymethoxyflavones Regulate against Aging-Associated Diseases: Advances in Biological Mechanisms Responsible for Their Regulation”的綜述論文，2024年12月25日被選為封面論文。
成果介紹
1. 随着全球老齡化人口比例逐年上升，與年齡相關的疾病，包括神經退行性疾病、代謝性疾病和心血管疾病，最近引起了食品科學家和營養學家的廣泛關注。
2. 多甲氧基黃酮（PMFs）是膳食類黃酮的一種，因其具有多種生物活性，包括抗氧化、抗炎、神經保護和代謝調節作用，已成為潛在的抗衰老候選物質。本綜述總結并讨論了PMFs對衰老的影響，詳細闡述了PMFs介導的調節作用與預防或治療各種衰老相關疾病的可能機制。此外，還從 PMFs 在體内的吸收、分布、代謝和排洩等方面詳細讨論了 PMFs 的生物學歸宿。特别關注了 PMF 的生物利用率與生物活性之間的關系，因為 PMF 的生物利用率低會嚴重影響其生物活性。
3. 總之，所有這些結論都有助于為進一步研究 PMF 對衰老的影響提供一個視角。
圖文賞析
TOC
Figure 1. Classification and chemical structures of citrus flavonoids, including representative compounds of commonly studied citrus polymethoxyflavones (PMFs).
Figure 2. (A) Schematic diagram of free radical theory in aging (upper) and summary of related cellular mechanisms and pathways over prevention from oxidative stress (lower), including structure–activity links of PMFs on their diverse antioxidant activities. (B) Potential anti-inflammatory signaling pathways and mechanisms of citrus PMFs.
Figure 3. (A) Schematic representation partially of the age-related diseases described grouped by organs or systems. (B) Neuroprotective effects of PMFs and related molecular mechanisms by inhibiting the activities of BACE1, promoting CREB phosphorylated levels and ChAT gene transcription, enhancing the level of ACh and the activity of nAChR.
Figure 4. Potential molecular mechanisms of metabolic syndrome regulatory effects of PMFs by lowering lipid effect and modulating gut homeostasis.
Figure 5. Schematic illustration of the identified targets that facilitate the anticardiovascular effects.
Figure 6. Role of PMFs in two major signaling pathways inducing bone formation (A,B) and inhibiting osteoclast activity (blocking RANKL synthesis) (C).
